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DHP CCB-Induced Peripheral Edema

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Personally, I like using dihydropyridine calcium channel blockers (DHP CCB) in my clinic when managing blood pressure (given no comorbid disease states). Why? Because it's the only first-line agent that's easy to titrate and doesn't require lab follow-up, which is a HUGE plus especially for those who have difficulty getting to the lab. However, the main caveat of using a DHP CCB is the famous peripheral edema, more specifically, bilateral ankle swellings. In pharmacy school, we learned that DHP CCB can cause dose-dependent peripheral edema in addition to constipation and, rarely, gingival hyperplasia (ya'll remember that?). But did you guys know that the risk of CCB-induced peripheral edema may be reduced if used with ACEs/ARBs? If you did, kudos to you. This is news to me and it blew my mind so I'm going to share it here :) (slide credit: Dr. Aziz-ur-Rehman) As seen above, the mechanism of action of peripheral edema is thought to be due to CCB's action

Hello.

My name is Young. I'm a brand-new clinical pharmacist starting out my career in an ambulatory care setting. In this blog, I would like to share my journey as an ambulatory care pharmacist! I'm a nerd when it comes to pathophysiology & pharmacology to truly UNDERSTAND how medications work, so I will also be sharing some educational posts as well. I hope that this blog will be a place where pharmacists, students, or other healthcare professionals can engage, learn, and share their experiences!